A Circular Statistical Method for Extracting Rotation Measures

We propose a new method for the extraction of Rotation Measure from spectral polarization data. The method is based on maximum likelihood analysis and takes into account the circular nature of the polarization data. The method is unbiased and statistically more efficient than the standard $\chi^2$ procedure. We also find that the method is computationally much faster than the standard $\chi^2$ procedure if the number of data points are very large.Comment: 17 pages, 5 figure

Towards a value-centric approach to education: Implications of changing practices in construction project management

This article explores two interdependent subjects underpinning how the built environment is produced: value and integrated teamwork. The concept of value is defined as the relationship between benefits received and costs incurred. Value thereby derives from the values of the judge and in multi-stakeholder construction projects, understanding each membera??s unique value proposition is complex, forming a catalyst for integrated teamwork and interdisciplinary ways of working. These subjects are reviewed in relation to the changes occurring in practice and how they can help inform new approaches to the education of built environment professionals, giving specific attention to construction project management education. In exploring these themes, the authors first review related project management research, before focusing on construction and current trends in practice. The paper then summarises research aimed at developing better theories of value and advancing integrated teamwork in construction. A framework aimed at facilitating a move to an educational model that encompasses a value-based and multidisciplinary approach is presented, followed by discussion and future work

Knowledge Representation for Web Navigation

Representations of domain knowledge range from those that are ontologically formal, semantically rich to those that are ontologically informal and semantically weak. Representations of knowledge are important in many tasks, one of which is the support of travel around information spaces through the identification and linking of concepts in a field. In this paper we explore how representations of ontologically informal, semantically weak domain knowledge as captured by the Simple Knowledge Organisation System (SKOS) can enable a system to take advantage of the large number of existing ontological representations to support semantic linking of Web based information and thus facilitate information travel

Document Navigation: Ontology or Knowledge Organization System?

Bioinformatics relies heavily on web resources for information gathering. Ontologies are being developed to fill the background knowledge needed to drive Semantic Web applications. This paper discusses how formal ontologies are not always suited for document navigation on the web. Converting ontologies into a model with looser semantics, allows cheap and rapid generation of useful knowledge systems. The message is that ontologies are not the only knowledge artefact needed; vocabularies and other classification schemes with weaker semantics have their role and are the best solution in certain circumstances

The cellular microscopy phenotype ontology

BACKGROUND: Phenotypic data derived from high content screening is currently annotated using free-text, thus preventing the integration of independent datasets, including those generated in different biological domains, such as cell lines, mouse and human tissues. DESCRIPTION: We present the Cellular Microscopy Phenotype Ontology (CMPO), a species neutral ontology for describing phenotypic observations relating to the whole cell, cellular components, cellular processes and cell populations. CMPO is compatible with related ontology efforts, allowing for future cross-species integration of phenotypic data. CMPO was developed following a curator-driven approach where phenotype data were annotated by expert biologists following the Entity-Quality (EQ) pattern. These EQs were subsequently transformed into new CMPO terms following an established post composition process. CONCLUSION: CMPO is currently being utilized to annotate phenotypes associated with high content screening datasets stored in several image repositories including the Image Data Repository (IDR), MitoSys project database and the Cellular Phenotype Database to facilitate data browsing and discoverability

Counteractive effects of antenatal glucocorticoid treatment on D1 receptor modulation of spatial working memory.

RATIONALE: Antenatal exposure to the glucocorticoid dexamethasone dramatically increases the number of mesencephalic dopaminergic neurons in rat offspring. However, the consequences of this expansion in midbrain dopamine (DA) neurons for behavioural processes in adulthood are poorly understood, including working memory that depends on DA transmission in the prefrontal cortex (PFC). OBJECTIVES: We therefore investigated the influence of antenatal glucocorticoid treatment (AGT) on the modulation of spatial working memory by a D1 receptor agonist and on D1 receptor binding and DA content in the PFC and striatum. METHODS: Pregnant rats received AGT on gestational days 16-19 by adding dexamethasone to their drinking water. Male offspring reared to adulthood were trained on a delayed alternation spatial working memory task and administered the partial D1 agonist SKF38393 (0.3-3 mg/kg) by systemic injection. In separate groups of control and AGT animals, D1 receptor binding and DA content were measured post-mortem in the PFC and striatum. RESULTS: SKF38393 impaired spatial working memory performance in control rats but had no effect in AGT rats. D1 binding was significantly reduced in the anterior cingulate cortex, prelimbic cortex, dorsal striatum and ventral pallidum of AGT rats compared with control animals. However, AGT had no significant effect on brain monoamine levels. CONCLUSIONS: These findings demonstrate that D1 receptors in corticostriatal circuitry down-regulate in response to AGT. This compensatory effect in D1 receptors may result from increased DA-ergic tone in AGT rats and underlie the resilience of these animals to the disruptive effects of D1 receptor activation on spatial working memory.The authors’ research is funded by the Wellcome Trust (grant number 086871/Z/08/Z), the MRC (G0701500), a joint award from the MRC (G1000183) and Wellcome Trust (093875/Z/10/ Z) in support of the Behavioral and Clinical Neuroscience Institute at Cambridge University, and an MRC strategic award to the Imperial College-Cambridge University-Manchester University (ICCAM) addiction cluster (G1000018).This is the final version of the article. It first appeared from Springer at http://dx.doi.org/10.1007/s00213-016-4405-8

The Sigma 13 (10-14) twin in alpha-Al2O3: A model for a general grain boundary

The atomistic structure and energetics of the Sigma 13 (10-14)[1-210] symmetrical tilt grain boundary in alpha-Al2O3 are studied by first-principles calculations based on the local-density-functional theory with a mixed-basis pseudopotential method. Three configurations, stable with respect to intergranular cleavage, are identified: one Al-terminated glide-mirror twin boundary, and two O-terminated twin boundaries, with glide-mirror and two-fold screw-rotation symmetries, respectively. Their relative energetics as a function of axial grain separation are described, and the local electronic structure and bonding are analysed. The Al-terminated variant is predicted to be the most stable one, confirming previous empirical calculations, but in contrast with high-resolution transmission electron microscopy observations on high-purity diffusion-bonded bicrystals, which resulted in an O-terminated structure. An explanation of this discrepancy is proposed, based on the different relative energetics of the internal interfaces with respect to the free surfaces

Ontology mapping for semantically enabled applications

In this review, we provide a summary of recent progress in ontology mapping (OM) at a crucial time when biomedical research is under a deluge of an increasing amount and variety of data. This is particularly important for realising the full potential of semantically enabled or enriched applications and for meaningful insights, such as drug discovery, using machine-learning technologies. We discuss challenges and solutions for better ontology mappings, as well as how to select ontologies before their application. In addition, we describe tools and algorithms for ontology mapping, including evaluation of tool capability and quality of mappings. Finally, we outline the requirements for an ontology mapping service (OMS) and the progress being made towards implementation of such sustainable services